Fri Dec 09 2022

55 articles - From Friday Dec 02 2022 to Friday Dec 09 2022

parm_toc.knit

Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews

Clin Gastroenterol Hepatol

Blood endotoxin levels as biomarker of non-alcoholic fatty liver disease: a systematic review and meta-analysis.

Our results support blood endotoxin levels as relevant diagnostic biomarker for NAFLD, both for disease detection as well as staging during disease progression, and might serve as surrogate marker of enhanced intestinal permeability in NAFLD.

Pubmed   Journal   ReadQx 

Dietary interventions for the treatment of inflammatory bowel diseases: an updated systematic review and meta-analysis.

Among the most robust dietary trials in IBD currently available, certainty of evidence remains very low or low. Nonetheless, emerging data suggest potential benefit with partial enteral nutrition for induction and maintenance of remission in CD. Reduction of red meat and refined carbohydrates might not reduce risk of CD relapse. As more dietary studies become available, the certainty of evidence could improve, thus allowing for more meaningful recommendations for patients.

Pubmed   Journal   ReadQx 

Gastrointest Endosc

Single Incision Needle Knife Biopsy for the Diagnosis of Gastrointestinal Subepithelial Tumors: A Systematic Review and Meta-Analysis.

SINK biopsy is a safe diagnostic procedure with a high technical and diagnostic success in patients with gastrointestinal SET. Further randomized controlled trials and direct comparison studies are needed to validate these findings.

Pubmed   Journal   ReadQx 


Original articles

RCT, clinical trials, retrospective studies, etc…

Am J Gastroenterol

Acute pancreatitis recurrences augment long-term pancreatic cancer risk.

Elevated PDAC risk following AP was not influenced by the etiology of AP (gallstones, smoking or alcohol). There is a higher PDAC risk 3-10 years following AP irrespective of etiology of AP, increases with the number of episodes of AP and is additive to higher PDAC risk due to CP.

Pubmed   Journal   ReadQx 

Modified Cap-Assisted Endoscopic Mucosal Resection Versus Endoscopic Submucosal Dissection for the Treatment of Rectal Neuroendocrine Tumors =10 mm: A Randomized Noninferiority Trial.

mEMR-C is noninferior to ESD with a similar complete resection rate. In addition, mEMR-C had shorter procedure duration time and lower hospitalization costs.

Pubmed   Journal   ReadQx 

Principles for Assessing Quality of Life in Patients With Crohn's Disease.

Patient-Reported Impact of Symptoms in CD provides an innovative and patient-centered framework for assessing quality of life in patients with CD, soliciting qualitative data from patient interviews, and using this to guide a cross-sectional study. Their findings should inform how clinicians guide conversations with their patients regarding quality of life.

Pubmed   Journal   ReadQx 

Clin Gastroenterol Hepatol

Risk stratification for sarcopenic obesity in subjects with nonalcoholic fatty liver disease.

The high-risk screening model may enable the identification of high-risk SO subjects with NAFLD.

Pubmed   Journal   ReadQx 

Upadacitinib Therapy Reduces Ulcerative Colitis Symptoms as Early as Day 1 of Induction Treatment.

Upadacitinib 45 mg QD provided rapid relief of UC symptoms from day 1.

Pubmed   Journal   ReadQx 

Gastrointest Endosc

Auxiliary diagnosis of subepithelial lesions by impedance measurement during endoscopic ultrasound guided fine-needle biopsy.

Auxiliary differential diagnosis between gastric GISTs and non-GISTs by the H-impedance measurement during EUS-FNB could be a good option especially when the lesion is smaller than 20 mm.

Pubmed   Journal   ReadQx 

Computer aided characterization of early cancer in Barrett's esophagus on i-scan magnification imaging - Multicenter international study.

On a selected sequence of frames per case (total of 11,471 frames) we used an exponentially weighted moving average of classifications on consecutive frames to characterize dysplasia. The network achieved a sensitivity of 92%, specificity of 84% and AUROC of 96% The mean assessment speed per frame was 0.0135 seconds (SD, + 0.006) CONCLUSION: Our network can characterize BE dysplasia with high accuracy and speed on high-quality magnification images and sequence of video frames moving it towards real time automated diagnosis.

Pubmed   Journal   ReadQx 

In-stent radiofrequency ablation with uncovered metal stent placement for tumor ingrowth/overgrowth causing self-expandable metal stent occlusion in distal malignant biliary obstruction: Multicenter propensity score matched study.

IS-RFA followed by uncovered SEMS is safe and feasible and may improve TRBO as a stent revision for occluded SEMS in pancreatobiliary cancer.

Pubmed   Journal   ReadQx 

INTRADUCTAL FULLY COVERED SELF-EXPANDING METAL STENT VERSUS MULTIPLE PLASTIC STENTS FOR TREATING BILIARY ANASTOMOTIC STRICTURES AFTER LIVER TRANSPLANTATION.

ID-FCSEMS for treatment of AS after LT provides similar stricture resolution and recurrence rates as MPS, though with a significant reduction of procedures needed.

Pubmed   Journal   ReadQx 

Usefulness of Texture and Color Enhancement Imaging (TXI) in Assessing Mucosal Healing in Patients with Ulcerative Colitis.

TXI can be used to identify populations with poor prognosis in MES 1, for which treatment intensification has been controversial.

Pubmed   Journal   ReadQx 

J Hepatol

Decreased propionyl-CoA metabolism facilitates metabolic reprogramming and promotes hepatocellular carcinoma.

Our study unveils novel features that the decline of ALDH6A1-mediated Pro-CoA metabolism contributes to metabolic remodeling and facilitates hepatocarcinogenesis. Pro-CoA, PLC and MCA may serve as novel metabolic biomarkers for diagnosis and therapy of HCC. Pro-CoA metabolism may provide potential targets for development of novel strategies against HCC. Impact and implications Our study presents new insights on metabolic reprogramming and hepatocarcinogenesis attribute to the decline of ALDH6A1-mediated propionyl-CoA. These findings may enrich molecular and metabolic indicators for physicians to improve clinical practice. These biomarkers may potentially be used for diagnosis and serve as targets for the development of therapeutic strategies against HCC.

Pubmed   Journal   ReadQx 

Risk of hepatic decompensation but not hepatocellular carcinoma decreases over time in patients with hepatitis B surface antigen loss.

HCC risk persists in patients after HBsAg loss, whereas the risk of hepatic decompensation decreases over time. Impact and implications Patients with chronic hepatitis B (CHB) still have a non-negligible risk of hepatocellular carcinoma (HCC) after 12 years of hepatitis B surface antigen (HBsAg) seroclearance, especially among those with cirrhosis. The risk of developing hepatic decompensation decreases over time after HBsAg seroclearance. In clinical practice, although CHB patients who cleared HBsAg have a more favourable clinical outcome than those who remain chronically infected, long-term HCC surveillance would still be necessary for cirrhotic patients and high-risk subgroups of non-cirrhotic patients after HBsAg seroclearance.

Pubmed   Journal   ReadQx 

Using mouse liver cancer models based on somatic genome editing to predict immune checkpoint inhibitor responses.

HCCs with genetic mutations driving hot tumors may be suitable for anti-PD-1 single treatment. HCCs with genetic mutations driving cold tumors may be suitable for combined treatment of anti-PD-1 and sorafenib. Impact and implications Genetic alterations of different driver genes in mouse liver cancers are associated with tumor-infiltrating CD8 + T cells and anti-PD-1 response. Mouse HCCs of different genetics can be grouped into hot and cold tumors by the level of tumor-infiltrating CD8 + T cells. This study provides proof-of-concept evidence to show that hot tumors are responsive to anti-PD-1 treatment while cold tumors are more suitable for combined treatment with anti-PD-1 and sorafenib. Our study might be beneficial to the design of patient stratification system for single or combined treatments involving anti-PD-1.

Pubmed   Journal   ReadQx 

Neurogastroenterol Motil

5xFAD mice do not have myenteric amyloidosis, dysregulation of neuromuscular transmission or gastrointestinal dysmotility.

5xFAD AD mice are not a robust model to study amyloidosis in the gut as these mice do not mimic myenteric neuronal dysfunction in AD patients with GI dysmotility. An AD animal model with enteric amyloidosis is required for further study.

Pubmed   Journal   ReadQx 

Artificial intelligence facilitates measuring reflux episodes and postreflux swallow-induced peristaltic wave index from impedance-pH studies in patients with reflux disease.

AI has the potential to accurately and efficiently measure impedance metrics including reflux episodes and PSPW index. AI can be a reliable adjunct for measuring novel impedance metrics for GERD in the near future.

Pubmed   Journal   ReadQx 

Effects of dexmedetomidine on pharyngeal swallowing and esophageal motility-A double-blind randomized cross-over study in healthy volunteers.

Dexmedetomidine induces effects on pharyngeal swallowing and esophageal motility, which should be considered in clinical patient management and also when a sedative agent for procedural sedation or for manometric examination is to be chosen.

Pubmed   Journal   ReadQx 

Is the Sars-CoV-2 virus a possible trigger agent for the development of achalasia?

SARS-CoV2 and its receptor expression in the LESm of achalasia patients who posteriorly had COVID-19 but not in the controls suggests that it could affect the myenteric plexus. Unlike achalasia, patients-COVID-19 have an imbalance between effector CD4 T cells and the regulatory mechanisms.

Pubmed   Journal   ReadQx 


Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Aliment Pharmacol Ther

Editorial: P-CABs for treatment of reflux oesophagitis-is this the future?

Pubmed   Journal   ReadQx 

Editorial: safety and efficacy of infliximab and corticosteroids in checkpoint inhibitor-induced colitis.

Pubmed   Journal   ReadQx 

Editorial: the acid test - can bile acids predict recurrence of Clostridioides difficile infection?

Pubmed   Journal   ReadQx 

Am J Gastroenterol

Gravity and the Gut: A Hypothesis of Irritable Bowel Syndrome.

This article concludes by considering the diagnostic and therapeutic implications of this new hypothesis and proposes experiments to support or reject this line of inquiry. It is hoped that the ideas in this thought experiment may also help encourage new or different ways of thinking about this common disorder.

Pubmed   Journal   ReadQx 

Immunotherapy for Cancer: Common Gastrointestinal, Liver, and Pancreatic Side Effects and Their Management.

Here, we review the commonly used US FDA-approved ICI and briefly outline their mechanism of action. We also describe the resulting collateral effects on the gastrointestinal tract, liver, and pancreas and discuss their management and prognosis.

Pubmed   Journal   ReadQx 

Clin Gastroenterol Hepatol

Metabolic health and outcomes in fatty liver: Does a name change matter?

Pubmed   Journal   ReadQx 

J Hepatol

Treatment of portal hypertension in patients with HCC at the era of Baveno VII.

In al patients, PHT complications should be prevented and treated adequately, especially if they present with advanced HCC. Those specific aspects will be discussed in the present review, taking into account the very recent data in HCC field.

Pubmed   Journal   ReadQx 


Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Am J Gastroenterol

A Rare Cause of Melena Leading to an Even Rarer Diagnosis.

Pubmed   Journal   ReadQx 

Calendar of Courses, Symposiums and Conferences.

Pubmed   Journal   ReadQx 

Response to Haseeb et al.

Pubmed   Journal   ReadQx 

Response to Hassan et al.

Pubmed   Journal   ReadQx 

Response to Scherübl.

Pubmed   Journal   ReadQx 

Clin Gastroenterol Hepatol

Rectal Cuff Adenocarcinoma: Rare Complication in Patients with Ileal Pouch Anal Anastomosis.

Pubmed   Journal   ReadQx 

Risk of Proximal Gastrointestinal Cancer after Positive Fecal Immunochemical Test.

Pubmed   Journal   ReadQx 

Endoscopy

A case of rectal diverticulitis resembling a submucosal tumor under colorectal endoscopy: a hitherto undescribed lesion.

Pubmed   Journal   ReadQx 

A new method to identify the afferent limb in balloon enteroscopy-assisted ERCP: Retention of gel mixed with contrast medium under fluoroscopy.

Pubmed   Journal   ReadQx 

A novel extracorporeal accessory traction device for gastric endoscopic submucosal dissection.

Pubmed   Journal   ReadQx 

Early duodenal cancer successfully treated by endoscopic submucosal dissection with an ultra-thin endoscope in spite of severe esophageal stricture.

Pubmed   Journal   ReadQx 

Endoscopic full-thickness resection is a safe and effective method for the treatment of sigmoid schwannomas.

Pubmed   Journal   ReadQx 

Endoscopic ultrasound-guided bile duct reconstruction after complete section following a car crash in a 5-year-old child with complete situs inversus.

Pubmed   Journal   ReadQx 

Ischemic polypectomy using a diagnostic-type double-balloon endoscope with a modified detachable snare.

Pubmed   Journal   ReadQx 

Peroral endoscopic myotomy for treatment of achalasia in a patient with congenital osteogenesis imperfecta and scoliosis.

Pubmed   Journal   ReadQx 

Refractory aortoesophageal fistulas after aortic stenting successfully closed using endoscopic submucosal dissection with clip closure.

Pubmed   Journal   ReadQx 

Symptomatic cholelithiasis and acute cholecystitis treated by EUS-guided gallbladder drainage with gallbladder toilette.

Pubmed   Journal   ReadQx 

Gastroenterology

Post-Colonoscopy Colorectal Cancer Etiologies in a Large Integrated United States Healthcare Setting.

Pubmed   Journal   ReadQx 

Race/Ethnicity, Stage-Specific Mortality and Cancer Treatment in Esophageal and Gastric Cancers: Surveillance Epidemiology and End Results (2000-2018).

Pubmed   Journal   ReadQx 


Letters&Replies

Letters to the editors and authors’ replies

Aliment Pharmacol Ther

Editorial: chronic hepatitis C with metabolic dysfunction-associated fatty liver disease - A model for adoption of Sustainable Development Goal 3.

Pubmed   Journal   ReadQx 

Editorial: safety and efficacy of infliximab and corticosteroids in checkpoint inhibitor-induced colitis-authors' reply.

Pubmed   Journal   ReadQx 

Editorial: the impact of COVID on the management of IBD flares: different care but similar outcomes-authors' reply.

Pubmed   Journal   ReadQx 

Editorial: ustekinumab during pregnancy-reassuring but still not enough. Authors' reply.

Pubmed   Journal   ReadQx 

Letter: elderly AS-AIH patients need more attention.

Pubmed   Journal   ReadQx 

J Hepatol

Comment on: Impact of the COVID-19 pandemic on liver disease-related mortality rates in the United States.

Pubmed   Journal   ReadQx 

Drug-induced liver injury due to nitrofurantoin: similar clinical features, but different HLA risk alleles in an independent cohort.

Pubmed   Journal   ReadQx 

Hyperhomocysteinemia predicts liver-related clinical outcomes in the general population.

Pubmed   Journal   ReadQx 

Reply to: Bepirovirsen / GSK3389404: antisense or TLR9 agonists?

Pubmed   Journal   ReadQx