55 articles - From Friday Dec 02 2022 to Friday Dec 09 2022
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
meta-analyses and systematic reviews
| Clin Gastroenterol Hepatol |
Blood endotoxin levels as biomarker of non-alcoholic fatty liver disease: a systematic review and meta-analysis. Our results support blood endotoxin levels as relevant diagnostic biomarker for NAFLD, both for disease detection as well as staging during disease progression, and might serve as surrogate marker of enhanced intestinal permeability in NAFLD. |
Dietary interventions for the treatment of inflammatory bowel diseases: an updated systematic review and meta-analysis. Among the most robust dietary trials in IBD currently available, certainty of evidence remains very low or low. Nonetheless, emerging data suggest potential benefit with partial enteral nutrition for induction and maintenance of remission in CD. Reduction of red meat and refined carbohydrates might not reduce risk of CD relapse. As more dietary studies become available, the certainty of evidence could improve, thus allowing for more meaningful recommendations for patients. |
| Gastrointest Endosc |
Single Incision Needle Knife Biopsy for the Diagnosis of Gastrointestinal Subepithelial Tumors: A Systematic Review and Meta-Analysis. SINK biopsy is a safe diagnostic procedure with a high technical and diagnostic success in patients with gastrointestinal SET. Further randomized controlled trials and direct comparison studies are needed to validate these findings. |
RCT, clinical trials, retrospective studies, etc…
| Am J Gastroenterol |
Acute pancreatitis recurrences augment long-term pancreatic cancer risk. Elevated PDAC risk following AP was not influenced by the etiology of AP (gallstones, smoking or alcohol). There is a higher PDAC risk 3-10 years following AP irrespective of etiology of AP, increases with the number of episodes of AP and is additive to higher PDAC risk due to CP. |
Modified Cap-Assisted Endoscopic Mucosal Resection Versus Endoscopic Submucosal Dissection for the Treatment of Rectal Neuroendocrine Tumors =10 mm: A Randomized Noninferiority Trial. mEMR-C is noninferior to ESD with a similar complete resection rate. In addition, mEMR-C had shorter procedure duration time and lower hospitalization costs. |
Principles for Assessing Quality of Life in Patients With Crohn's Disease. Patient-Reported Impact of Symptoms in CD provides an innovative and patient-centered framework for assessing quality of life in patients with CD, soliciting qualitative data from patient interviews, and using this to guide a cross-sectional study. Their findings should inform how clinicians guide conversations with their patients regarding quality of life. |
| Clin Gastroenterol Hepatol |
| Gastrointest Endosc |
Auxiliary diagnosis of subepithelial lesions by impedance measurement during endoscopic ultrasound guided fine-needle biopsy. Auxiliary differential diagnosis between gastric GISTs and non-GISTs by the H-impedance measurement during EUS-FNB could be a good option especially when the lesion is smaller than 20 mm. |
Computer aided characterization of early cancer in Barrett's esophagus on i-scan magnification imaging - Multicenter international study. On a selected sequence of frames per case (total of 11,471 frames) we used an exponentially weighted moving average of classifications on consecutive frames to characterize dysplasia. The network achieved a sensitivity of 92%, specificity of 84% and AUROC of 96% The mean assessment speed per frame was 0.0135 seconds (SD, + 0.006) CONCLUSION: Our network can characterize BE dysplasia with high accuracy and speed on high-quality magnification images and sequence of video frames moving it towards real time automated diagnosis. |
In-stent radiofrequency ablation with uncovered metal stent placement for tumor ingrowth/overgrowth causing self-expandable metal stent occlusion in distal malignant biliary obstruction: Multicenter propensity score matched study. IS-RFA followed by uncovered SEMS is safe and feasible and may improve TRBO as a stent revision for occluded SEMS in pancreatobiliary cancer. |
INTRADUCTAL FULLY COVERED SELF-EXPANDING METAL STENT VERSUS MULTIPLE PLASTIC STENTS FOR TREATING BILIARY ANASTOMOTIC STRICTURES AFTER LIVER TRANSPLANTATION. ID-FCSEMS for treatment of AS after LT provides similar stricture resolution and recurrence rates as MPS, though with a significant reduction of procedures needed. |
| J Hepatol |
Decreased propionyl-CoA metabolism facilitates metabolic reprogramming and promotes hepatocellular carcinoma. Our study unveils novel features that the decline of ALDH6A1-mediated Pro-CoA metabolism contributes to metabolic remodeling and facilitates hepatocarcinogenesis. Pro-CoA, PLC and MCA may serve as novel metabolic biomarkers for diagnosis and therapy of HCC. Pro-CoA metabolism may provide potential targets for development of novel strategies against HCC. Impact and implications Our study presents new insights on metabolic reprogramming and hepatocarcinogenesis attribute to the decline of ALDH6A1-mediated propionyl-CoA. These findings may enrich molecular and metabolic indicators for physicians to improve clinical practice. These biomarkers may potentially be used for diagnosis and serve as targets for the development of therapeutic strategies against HCC. |
Risk of hepatic decompensation but not hepatocellular carcinoma decreases over time in patients with hepatitis B surface antigen loss. HCC risk persists in patients after HBsAg loss, whereas the risk of hepatic decompensation decreases over time. Impact and implications Patients with chronic hepatitis B (CHB) still have a non-negligible risk of hepatocellular carcinoma (HCC) after 12 years of hepatitis B surface antigen (HBsAg) seroclearance, especially among those with cirrhosis. The risk of developing hepatic decompensation decreases over time after HBsAg seroclearance. In clinical practice, although CHB patients who cleared HBsAg have a more favourable clinical outcome than those who remain chronically infected, long-term HCC surveillance would still be necessary for cirrhotic patients and high-risk subgroups of non-cirrhotic patients after HBsAg seroclearance. |
Using mouse liver cancer models based on somatic genome editing to predict immune checkpoint inhibitor responses. HCCs with genetic mutations driving hot tumors may be suitable for anti-PD-1 single treatment. HCCs with genetic mutations driving cold tumors may be suitable for combined treatment of anti-PD-1 and sorafenib. Impact and implications Genetic alterations of different driver genes in mouse liver cancers are associated with tumor-infiltrating CD8 + T cells and anti-PD-1 response. Mouse HCCs of different genetics can be grouped into hot and cold tumors by the level of tumor-infiltrating CD8 + T cells. This study provides proof-of-concept evidence to show that hot tumors are responsive to anti-PD-1 treatment while cold tumors are more suitable for combined treatment with anti-PD-1 and sorafenib. Our study might be beneficial to the design of patient stratification system for single or combined treatments involving anti-PD-1. |
| Neurogastroenterol Motil |
5xFAD mice do not have myenteric amyloidosis, dysregulation of neuromuscular transmission or gastrointestinal dysmotility. 5xFAD AD mice are not a robust model to study amyloidosis in the gut as these mice do not mimic myenteric neuronal dysfunction in AD patients with GI dysmotility. An AD animal model with enteric amyloidosis is required for further study. |
Artificial intelligence facilitates measuring reflux episodes and postreflux swallow-induced peristaltic wave index from impedance-pH studies in patients with reflux disease. AI has the potential to accurately and efficiently measure impedance metrics including reflux episodes and PSPW index. AI can be a reliable adjunct for measuring novel impedance metrics for GERD in the near future. |
Effects of dexmedetomidine on pharyngeal swallowing and esophageal motility-A double-blind randomized cross-over study in healthy volunteers. Dexmedetomidine induces effects on pharyngeal swallowing and esophageal motility, which should be considered in clinical patient management and also when a sedative agent for procedural sedation or for manometric examination is to be chosen. |
Is the Sars-CoV-2 virus a possible trigger agent for the development of achalasia? SARS-CoV2 and its receptor expression in the LESm of achalasia patients who posteriorly had COVID-19 but not in the controls suggests that it could affect the myenteric plexus. Unlike achalasia, patients-COVID-19 have an imbalance between effector CD4 T cells and the regulatory mechanisms. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Aliment Pharmacol Ther |
| Am J Gastroenterol |
Gravity and the Gut: A Hypothesis of Irritable Bowel Syndrome. This article concludes by considering the diagnostic and therapeutic implications of this new hypothesis and proposes experiments to support or reject this line of inquiry. It is hoped that the ideas in this thought experiment may also help encourage new or different ways of thinking about this common disorder. |
Immunotherapy for Cancer: Common Gastrointestinal, Liver, and Pancreatic Side Effects and Their Management. Here, we review the commonly used US FDA-approved ICI and briefly outline their mechanism of action. We also describe the resulting collateral effects on the gastrointestinal tract, liver, and pancreas and discuss their management and prognosis. |
| Clin Gastroenterol Hepatol |
| J Hepatol |
Treatment of portal hypertension in patients with HCC at the era of Baveno VII. In al patients, PHT complications should be prevented and treated adequately, especially if they present with advanced HCC. Those specific aspects will be discussed in the present review, taking into account the very recent data in HCC field. |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Am J Gastroenterol |
| Clin Gastroenterol Hepatol |
| Endoscopy |
| Gastroenterology |
Letters to the editors and authors’ replies
| Aliment Pharmacol Ther |
| J Hepatol |